The BTK Polyclonal Antibody (CAB1576) is a valuable tool for researchers studying the BTK protein, a key player in B-cell receptor signaling and immune response. This antibody is raised in rabbits and has been validated for use in Western blot applications, allowing for the detection and analysis of BTK in a variety of cell types.BTK, also known as Bruton's tyrosine kinase, is essential for B-cell development and function, making it a target of interest in research focused on immune disorders, leukemia, and other cancers.
Dysregulation of BTK activity has been implicated in various diseases, making it crucial to understand its role in immune cell signaling and disease pathology.The BTK Polyclonal Antibody is highly reactive with human samples, providing researchers with a reliable tool for studying BTK expression and function in different experimental settings. Its specificity and sensitivity make it an ideal choice for studies aiming to unravel the complex mechanisms underlying B-cell signaling and immune response regulation.
Product Name:
BTK Rabbit Polyclonal Antibody
SKU:
CAB1576
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-240 of human BTK (NP_000052.1).
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
695
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded mouse spleen using BTK Rabbit pAb (CAB1576) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
