Anti-BSN Antibody (PACO20963)

Antibody Name:	BSN Antibody (PACO20963)
Antibody SKU:	PACO20963
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide of human BSN

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20963(BSN Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20963(BSN Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

Neurotransmitters are released from a specific site in the axon terminal called the active zone, which is composed of synaptic vesicles and a meshwork of cytoskeleton underlying the plasma membrane. The protein encoded by this gene is thought to be a scaffolding protein involved in organizing the presynaptic cytoskeleton. The gene is expressed primarily in neurons in the brain. A similar gene product in rodents is concentrated in the active zone of axon terminals and tightly associated with cytoskeletal structures, and is essential for regulating neurotransmitter release from a subset of synapses.

Synonyms:

bassoon presynaptic cytomatrix protein

UniProt Protein Function:	BSN: involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Essential in regulated neurotransmitter release from a subset of brain glutamatergic synapses. Involved in the formation of the retinal photoreceptor ribbon synapses. Interacts with CAST1, RIMS1 and UNC13A. Part of a complex consisting of ERC2, RIMS1 and BSN. Localized to the active zone of presynaptic density. Mice lacking functional BSN showed a reduced excitability attributed to inactivation of a fraction of brain glutamatergic synapses. At these synapses, vesicles are clustered and docked in normal numbers, but are unable to fuse. In retina, mutants lacking functional BSN showed normal retinal anatomy, but synapses lacked anchoring of the photoreceptor ribbon to the presynaptic active zone resulting in impaired photoreceptor synaptic transmission. Two alternatively spliced isoforms have been reported.
UniProt Protein Details:	Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 3p21.31 Cellular Component: axon; cell junction; cell soma; cell surface; dendrite; excitatory synapse; nucleus; presynaptic active zone; trans-Golgi network Molecular Function:metal ion binding Biological Process: synaptic transmission; synaptogenesis
NCBI Summary:	Neurotransmitters are released from a specific site in the axon terminal called the active zone, which is composed of synaptic vesicles and a meshwork of cytoskeleton underlying the plasma membrane. The protein encoded by this gene is thought to be a scaffolding protein involved in organizing the presynaptic cytoskeleton. The gene is expressed primarily in neurons in the brain. A similar gene product in rodents is concentrated in the active zone of axon terminals and tightly associated with cytoskeletal structures, and is essential for regulating neurotransmitter release from a subset of synapses. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9UPA5
NCBI GenInfo Identifier:	91208420
NCBI Gene ID:	8927
NCBI Accession:	NP_003449.2
UniProt Secondary Accession:	Q9UPA5,O43161, Q7LGH3,
UniProt Related Accession:	Q9UPA5
Molecular Weight:	416,469 Da
NCBI Full Name:	protein bassoon
NCBI Synonym Full Names:	bassoon presynaptic cytomatrix protein
NCBI Official Symbol:	BSN
NCBI Official Synonym Symbols:	ZNF231
NCBI Protein Information:	protein bassoon
UniProt Protein Name:	Protein bassoon
UniProt Synonym Protein Names:	Zinc finger protein 231
Protein Family:	Protein bassoon
UniProt Gene Name:	BSN
UniProt Entry Name:	BSN_HUMAN

ELISA Kits

Human BSN / Protein bassoon ELISA Kit

Human Protein bassoon (BSN) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)