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Anti-BSG Antibody (CAB13954)

SKU:
CAB13954
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
$167 - $503
Frequently bought together:

Description

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Anti-BSG Antibody (CAB13954)

The BSG Polyclonal Antibody (CAB13954) is a critical tool for studies involving BSG, a cell surface molecule known for its role in tumor progression and metastasis. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the BSG protein, researchers can effectively detect and analyze its expression in various cell types, making it an ideal choice for investigations in cancer biology and metastasis research.BSG, also known as CD147 or EMMPRIN, is a multifunctional glycoprotein known for its involvement in cancer cell invasion, metastasis, and angiogenesis.

Its overexpression has been linked to poor prognosis in various types of cancer, making it a promising therapeutic target for anti-cancer drug development. By studying the role of BSG in tumor growth and spreading, researchers can gain valuable insights into potential treatment strategies for combating cancer progression.Overall, the BSG Polyclonal Antibody (CAB13954) offers researchers a reliable tool for investigating the significance of BSG in cancer biology and metastasis, ultimately contributing to the development of targeted therapies for combating cancer progression.

Antibody Name:Anti-BSG Antibody
Antibody SKU:CAB13954
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 45-200 of human BSG (NP_940991.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, Y79, Mouse brain, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 45-200 of human BSG (NP_940991.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DSAT EVTG HRWL KGGV VLKE DALP GQKT EFKV DSDD QWGE YSCV FLPE PMGT ANIQ LHGP PRVK AVKS SEHI NEGE TAML VCKS ESVP PVTD WAWY KITD SEDK ALMN GSES RFFV SSSQ GRSE LHIE NLNM EADP GQYR CNGT SSKG SDQA IITL
Gene ID:682
Uniprot:P35613
Cellular Location:Cell membrane, Melanosome, Single-pass type I membrane protein
Calculated MW:19kDa/22kDa/29kDa/42kDa
Observed MW:38-65KDa
Synonyms:BSG, 5F7, CD147, EMMPRIN, OK, TCSF, basigin
Background:The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:BSG: Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor. Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms a complex with MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with ATP1B2, MAG and L1CAM. Interacts with AJAP1. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: acrosomal membrane; focal adhesion; Golgi membrane; integral to plasma membrane; lipid raft; melanosome; membrane; mitochondrion; plasma membrane; sarcolemma

Molecular Function:mannose binding; protein binding

Biological Process: blood coagulation; cell surface receptor linked signal transduction; cellular metabolic process; decidualization; embryo implantation; extracellular matrix disassembly; extracellular matrix organization and biogenesis; leukocyte migration; odontogenesis of dentine-containing teeth; pyruvate metabolic process; response to cAMP; response to mercury ion; response to peptide hormone stimulus

Disease: Blood Group--ok

NCBI Summary:The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P35613
NCBI GenInfo Identifier:51704273
NCBI Gene ID:682
NCBI Accession:P35613.2
UniProt Secondary Accession:P35613,Q7Z796, Q8IZL7, A6NJW1, D3YLG5,
UniProt Related Accession:P35613
Molecular Weight:22,764 Da
NCBI Full Name:Basigin
NCBI Synonym Full Names:basigin (Ok blood group)
NCBI Official Symbol:BSG  
NCBI Official Synonym Symbols:OK; 5F7; TCSF; CD147; EMMPRIN  
NCBI Protein Information:basigin
UniProt Protein Name:Basigin
UniProt Synonym Protein Names:5F7; Collagenase stimulatory factor; Extracellular matrix metalloproteinase inducer; EMMPRIN; Leukocyte activation antigen M6; OK blood group antigen; Tumor cell-derived collagenase stimulatory factor; TCSF; CD_antigen: CD147
Protein Family:Basigin
UniProt Gene Name:BSG  
UniProt Entry Name:BASI_HUMAN
Anti-BSG Antibody (CAB13954)Western blot analysis of extracts of various cell lines, using BSG antibody (CAB13954) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

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