The BRWD1 Polyclonal Antibody (PAC020872) is a valuable tool for research involving BRWD1, a protein involved in chromatin remodeling and gene regulation. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding specifically to the BRWD1 protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for studies in genetics and epigenetics.BRWD1, also known as bromodomain and WD repeat domain containing 1, plays a crucial role in regulating gene expression by modifying chromatin structure. Its involvement in chromatin remodeling processes makes it a key player in controlling gene transcription and ultimately cellular functions.
Understanding the function of BRWD1 is essential for unraveling its role in various biological processes and diseases, including cancer and developmental disorders.By using the BRWD1 Polyclonal Antibody (PAC020872), researchers can delve deeper into the mechanisms by which BRWD1 influences gene regulation and cellular functions. This antibody serves as a reliable tool for studying the functions of BRWD1 in both normal physiological processes and disease states, paving the way for potential therapeutic interventions targeting BRWD1-related pathways.
Antibody Name:
BRWD1 Antibody (PACO20872)
Antibody SKU:
PACO20872
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:20-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human BRWD1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20872(BRWD1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20872(BRWD1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acid, typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.
Synonyms:
bromodomain and WD repeat domain containing 1
UniProt Protein Function:
May be a transcriptional activator. May be involved in chromatin remodeling. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
NCBI Summary:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011]
