The BRS3 Polyclonal Antibody (PACO05149) is a valuable tool for researchers studying the Bombesin receptor subtype 3 (BRS3), a G-protein coupled receptor involved in various physiological processes. This rabbit-derived antibody is highly specific for human samples and is validated for use in Western blot applications. By binding to the BRS3 protein, researchers can analyze and detect its expression in different cell types, making it ideal for studies in neurobiology and metabolism.BRS3 plays a significant role in regulating energy balance, food intake, and metabolism, making it a potential target for therapeutic interventions in obesity and related metabolic disorders.
Understanding the mechanisms underlying BRS3 signaling is crucial for developing effective treatments that target this receptor in metabolic diseases. The BRS3 Polyclonal Antibody is a valuable tool for researchers aiming to unravel the complexities of BRS3 function and its implications in physiology and disease.
Synthesized peptide derived from the Internal region of human BRS-3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
BRS3; Bombesin receptor subtype-3; BRS-3
UniProt Protein Function:
BRS3: Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integralChromosomal Location of Human Ortholog: Xq26.3Cellular Component: neuron projection; cell soma; integral to membrane; plasma membraneMolecular Function: bombesin receptor activityBiological Process: regulation of blood pressure; bombesin receptor signaling pathway; glucose metabolic process; adult feeding behavior
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011]
