The BRIP1 Polyclonal Antibody (CAB6804) is a valuable tool for researchers investigating BRIP1, a protein involved in DNA repair and maintenance. This antibody, generated in rabbits, shows high reactivity with human samples and has been validated for use in Western blotting and other applications. By binding specifically to the BRIP1 protein, this antibody enables researchers to detect and analyze BRIP1 expression in a variety of cell types, making it an essential component in studies related to DNA repair mechanisms and cancer research.BRIP1, also known as BRCA1-interacting protein 1, plays a crucial role in maintaining genomic stability by participating in DNA repair pathways.
Mutations in the BRIP1 gene have been associated with an increased risk of developing certain types of cancer, making it a promising target for therapeutic interventions. Understanding the function and regulation of BRIP1 is essential for developing targeted therapies and diagnostic tools for cancer patients. Researchers looking to explore the role of BRIP1 in DNA repair and cancer biology will find the BRIP1 Polyclonal Antibody (CAB6804) to be a valuable asset in their studies.
Product Name:
BRIP1 Rabbit Polyclonal Antibody
SKU:
CAB6804
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human BRIP1 (NP_114432.2).
The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations.
Purification Method:
Affinity purification
Gene ID:
83990
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using BRIP1 antibody (CAB6804) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
