The BRINP3 Polyclonal Antibody (CAB18237) is a valuable tool for researchers studying BRINP3, a brain-specific protein involved in neurodevelopment and neurodegenerative diseases. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the BRINP3 protein, this antibody allows for the detection and analysis of BRINP3 levels in various cell types, making it an essential reagent for studies in neuroscience and brain-related disorders.
BRINP3, also known as BMP/retinoic acid inducible neural-specific protein 3, is known to play a crucial role in neuronal differentiation and survival. Its dysregulation has been implicated in conditions such as Alzheimer's disease, Parkinson's disease, and schizophrenia. Therefore, investigating the function and expression of BRINP3 is vital for understanding the mechanisms underlying these neurological disorders and developing targeted therapies to treat them.
Product Name:
BRINP3 Rabbit Polyclonal Antibody
SKU:
CAB18237
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 240-500 of human BRINP3 (NP_950252.1).
This gene is overexpressed in pituitary tumors but is underexpressed in tongue squamous cell carcinomas, ulcerative colitis, and peri-implantitis. Polymorphisms that increase expression of this gene have been shown to increase vascular inflammation, and an association of this gene with myocardial infarction has been demonstrated. Finally, hypermethylation of this gene may find usefulness as a biomarker for gastric cancer. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
339479
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using BRINP3 Rabbit pAb (CAB18237) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
