The BRG1 Rabbit Monoclonal Antibody (CAB19556) is a valuable tool for researchers studying BRG1, a critical protein involved in chromatin remodeling and gene regulation. This antibody, generated in rabbits, boasts high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the BRG1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component of studies in epigenetics, gene expression, and cancer research.BRG1, a member of the SWI/SNF chromatin remodeling complex, plays a crucial role in regulating gene transcription and chromatin structure.
Dysregulation of BRG1 has been linked to various diseases, including cancer, developmental disorders, and neurological conditions. Understanding the function and regulation of BRG1 is essential for uncovering potential therapeutic targets for these diseases and advancing personalized medicine approaches.Whether investigating the role of BRG1 in cancer progression, gene expression dynamics, or cellular differentiation, the BRG1 Rabbit Monoclonal Antibody (CAB19556) is a reliable and specific tool for researchers seeking to unravel the complex mechanisms of chromatin remodeling and gene regulation.
Product Name:
BRG1/SMARCA4 Rabbit Monoclonal Antibody
SKU:
CAB19556
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human BRG1/SMARCA4 (P51532).
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI,which is required for transcriptional activation of genes normally repressed by chromatin. In addition,this protein can bind BRCA1,as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6597
Clone Number:
ARC0035
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using BRG1/SMARCA4 antibody (CAB19556) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
