BRG1/SMARCA4 Rabbit Monoclonal Antibody (CAB19556)
- SKU:
- CAB19556
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Neuroscience
Description
Product Name: | BRG1/SMARCA4 Rabbit Monoclonal Antibody |
SKU: | CAB19556 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human BRG1/SMARCA4 (P51532). |
Sequence: | LQMA VQGK RPMP GMQQ QMPT LPPP SVSA TGPG PGPG PGPG PGPG PAPP NYSR PHGM GGPN MPPP GPSG VPPG MPGQ PPGG PPKP WPEG PMAN AAAP TSTP Q |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | BRG1; CSS4; SNF2; SWI2; MRD16; RTPS2; BAF190; SNF2L4; SNF2LB; hSNF2b; BAF190A; SNF2-beta; BRG1/SMARCA4 |
Positive Sample: | HeLa,Jurkat,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus |
Calculated MW: | 185kDa |
Observed MW: | 250kDa |
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI,which is required for transcriptional activation of genes normally repressed by chromatin. In addition,this protein can bind BRCA1,as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 6597 |
Clone Number: | ARC0035 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |