The BRE Polyclonal Antibody (CAB15122) is a valuable tool for researchers studying BRE, a protein involved in DNA damage response and repair. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the BRE protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in molecular biology and cancer research.BRE, also known as brain and reproductive expression protein, plays a crucial role in maintaining genomic stability and preventing the accumulation of mutations that can lead to cancer development.
Understanding the function of BRE is essential for uncovering its potential as a therapeutic target in cancer treatment and for furthering our knowledge of DNA damage response mechanisms. Researchers interested in investigating the role of BRE in cellular processes related to cancer progression and treatment will find this antibody to be a valuable resource in their studies.
Product Name:
BRE Rabbit Polyclonal Antibody
SKU:
CAB15122
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 51-229 of human BRE (NP_954661.1).
This gene encodes an anti-apoptotic, death receptor-associated protein that interacts with tumor necrosis factor-receptor-1. The encoded protein acts as an adapter in several protein complexes, including the BRCA1-A complex and the BRISC complex. The BRCA1-A complex possesses ubiquitinase activity and targets sites of double strand DNA breaks, while the BRISC complex exhibits deubiquitinase activity and is involved in mitotic spindle assembly. This gene is upregulated in several types of cancer.
Purification Method:
Affinity purification
Gene ID:
9577
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using BRE Rabbit pAb (CAB15122) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
