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BRD8 Antibody (PACO08044)

SKU:
PACO08044
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459
Frequently bought together:

Description

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BRD8 Antibody (PACO08044)

The BRD8 Polyclonal Antibody (PACO08044) is a valuable tool for research focused on BRD8, a key protein involved in chromatin remodeling and transcriptional regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been rigorously tested for use in Western blot applications. By targeting the BRD8 protein, researchers can effectively study its function and expression levels across a variety of cell types, making it a versatile tool for studies in epigenetics and gene regulation.

BRD8 is a member of the bromodomain-containing protein family, known for its role in modulating gene expression through interactions with chromatin. Its involvement in various cellular processes, such as cell proliferation and differentiation, highlights its importance in developmental biology and cancer research. By utilizing the BRD8 antibody, researchers can gain valuable insights into the mechanisms underlying these processes, paving the way for potential therapeutic interventions targeting BRD8-related pathways.

Antibody Name:BRD8 Antibody (PACO08044)
Antibody SKU:PACO08044
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human BRD8
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity Purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:bromodomain containing 8;BRD8;SMAP;SMAP2;p120 ;
UniProt Protein Function:BRD8 iso1: May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressorChromosomal Location of Human Ortholog: 5q31Cellular Component: nucleoplasm; NuA4 histone acetyltransferase complex; mitochondrion; nucleusMolecular Function: thyroid hormone receptor activity; transcription factor activityBiological Process: regulation of transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; intracellular receptor-mediated signaling pathway; cell surface receptor linked signal transduction; regulation of transcription, DNA-dependent; transcription, DNA-dependent; regulation of growth; signal transduction
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Multiple alternatively spliced transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2014]
UniProt Code:Q9H0E9
NCBI GenInfo Identifier:313104080
NCBI Gene ID:10902
NCBI Accession:Q9H0E9.2
UniProt Secondary Accession:Q9H0E9,O43178, Q15355, Q58AB0, Q59GN0, Q969M9
UniProt Related Accession:Q9H0E9
Molecular Weight:1235
NCBI Full Name:Bromodomain-containing protein 8
NCBI Synonym Full Names:bromodomain containing 8
NCBI Official Symbol:BRD8  
NCBI Official Synonym Symbols:SMAP; p120; SMAP2  
NCBI Protein Information:bromodomain-containing protein 8; trCP120; skeletal muscle abundant protein 2; thyroid hormone receptor coactivating protein of 120 kDa
UniProt Protein Name:Bromodomain-containing protein 8
UniProt Synonym Protein Names:Skeletal muscle abundant protein; Skeletal muscle abundant protein 2; Thyroid hormone receptor coactivating protein of 120 kDa; TrCP120; p120
Protein Family:Bromodomain-containing protein
UniProt Gene Name:BRD8  
UniProt Entry Name:BRD8_HUMAN

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