The BRD2 Rabbit Polyclonal Antibody (CAB18229) is a valuable tool for researchers studying the BRD2 protein, a key player in epigenetic regulation and gene expression. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting BRD2 in human samples, making it an excellent choice for Western blot and immunohistochemistry applications.BRD2 is a member of the bromodomain and extra-terminal domain (BET) family of proteins, known for their involvement in chromatin remodeling and transcriptional activation. As a crucial epigenetic regulator, BRD2 is implicated in various cellular processes such as cell cycle progression, differentiation, and development.
Dysregulation of BRD2 has been linked to cancer, neurological disorders, and inflammatory diseases, underscoring its importance in biomedical research.By utilizing the BRD2 Rabbit Polyclonal Antibody, researchers can investigate the expression levels and localization of BRD2 in different cell types and tissues, providing insight into its functional roles in health and disease. This antibody is a valuable asset for studies in molecular biology, oncology, and pharmacology, ultimately contributing to the advancement of therapeutic strategies targeting BRD2-related conditions.
Product Name:
BRD2 Rabbit Polyclonal Antibody
SKU:
CAB18229
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human BRD2 (NP_005095.1).
This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
6046
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using BRD2 Rabbit pAb (CAB18229) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
