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BRD2 Monoclonal Antibody

SKU:
CAB23166
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€139 - €529
Frequently bought together:

Description

BRD2 Monoclonal Antibody (CAB23166)

The BRD2 Monoclonal Antibody is a crucial tool for researchers studying BRD2, a protein involved in epigenetic regulation and gene expression. This antibody is specifically designed for use in immunohistochemistry and Western blot applications, allowing for precise detection and analysis of BRD2 in various experimental settings.BRD2, a member of the bromodomain and extra-terminal (BET) protein family, plays a key role in chromatin remodeling and transcriptional activation. Its dysregulation has been implicated in various diseases, including cancer and inflammatory disorders. By targeting BRD2 with this monoclonal antibody, researchers can gain valuable insights into its function and potential therapeutic applications.

This antibody offers high specificity and sensitivity, enabling reliable detection of BRD2 in both normal and diseased tissues. Its versatility makes it an invaluable tool for research into epigenetics, gene regulation, and the development of targeted therapies. With the BRD2 Monoclonal Antibody, researchers can delve deeper into the intricate mechanisms underlying disease pathology and explore new avenues for therapeutic intervention.

Product Name:BRD2 Monoclonal Antibody
Product Code:CAB23166
Reactivity:Human, Mouse
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC56992
Reactivity:Human, Mouse
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:Jurkat, HeLa, MCF7, RAW 264.7
Cellular Location:Nucleus

This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatibility complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-345 of human BRD2 (NP_005095.1).
Sequence:MLQNV TPHNK LPGEG NAGLL GLGPE AAAPG KRIRK PSLLY EGFES PTMAS VPALQ LTPAN PPPPE VSNPK KPGRV TNQLQ YLHKV VMKAL WKHQF AWPFR QPVDA VKLGL PDYHK IIKQP MDMGT IKRRL ENNYY WAASE CMQDF NTMFT NCYIY NKPTD DIVLM AQTLE KIFLQ KVASM PQEEQ ELVVT IPKNS HKKGA KLAAL QGSVT SAHQV PAVSS VSHTA LYTPP PEIPT TVLNI PHPSV ISSPL LKSLH SAGPP LLAVT AAPPA QPLAK KKGVK RKADT TTPTP TAILA PGSPA SPPGS LEPKA ARLPP MRRES GRPIK PPRKD LPDSQ QQHQS SKKGK
Synonyms:FSH, NAT, RNF3, FSRG1, RING3, FSHRG1, D6S113E, O27.1.1, BRD2-IT1
Calculated MW:88kDa
Observed MW:112kDa

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