BRCC3 Rabbit Polyclonal Antibody (CAB7995)
- SKU:
- CAB7995
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Product Name: | BRCC3 Rabbit Polyclonal Antibody |
SKU: | CAB7995 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-316 of human BRCC3 (NP_077308.1). |
Sequence: | MAVQ VVQA VQAV HLES DAFL VCLN HALS TEKE EVMG LCIG ELND DTRS DSKF AYTG TEMR TVAE KVDA VRIV HIHS VIIL RRSD KRKD RVEI SPEQ LSAA STEA ERLA ELTG RPMR VVGW YHSH PHIT VWPS HVDV RTQA MYQM MDQG FVGL IFSC FIED KNTK TGRV LYTC FQSI QAQK SSES LHGP RDFW SSSQ HISI EGQK EEER YERI EIPI HIVP HVTI GKVC LESA VELP KILC QEEQ DAYR RIHS LTHL DSVT KIHN GSVF TKNL CSQM SAVS GPLL QWLE DRLE QNQQ HLQE LQQE KEEL MQEL SSLE |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | C6.1A; BRCC36; CXorf53; BRCC3 |
Positive Sample: | HeLa,MCF7,Jurkat,293T,Mouse liver,Mouse kidney,Mouse brain,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 36kDa |
Observed MW: | 33kDa/36kDa |
This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.
Purification Method: | Affinity purification |
Gene ID: | 79184 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |