BRCA2 Rabbit Polyclonal Antibody (CAB2435)
- SKU:
- CAB2435
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
Product Name: | BRCA2 Rabbit Polyclonal Antibody |
SKU: | CAB2435 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1400-1600 of BRCA2 (NP_000050.3). |
Sequence: | KESF NKIV NFFD QKPE ELHN FSLN SELH SDIR KNKM DILS YEET DIVK HKIL KESV PVGT GNQL VTFQ GQPE RDEK IKEP TLLG FHTA SGKK VKIA KESL DKVK NLFD EKEQ GTSE ITSF SHQW AKTL KYRE ACKD LELA CETI EITA APKC KEMQ NSLN N |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | FAD; FACD; FAD1; GLM3; BRCC2; FANCD; PNCA2; FANCD1; XRCC11; BROVCA2; BRCA2 |
Positive Sample: | Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center. |
Calculated MW: | 384kDa |
Observed MW: | 380kDa |
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The largest exon in both genes is exon 11, which harbors the most important and frequent mutations in breast cancer patients. The BRCA2 gene was found on chromosome 13q12.3 in human. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.
Purification Method: | Affinity purification |
Gene ID: | 675 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |