B-Raf Rabbit Polyclonal Antibody (CAB2988)
- SKU:
- CAB2988
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | B-Raf Rabbit Polyclonal Antibody |
SKU: | CAB2988 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 153-313 of human B-Raf (NP_004324.2). |
Sequence: | QKPI VRVF LPNK QRTV VPAR CGVT VRDS LKKA LMMR GLIP ECCA VYRI QDGE KKPI GWDT DISW LTGE ELHV EVLE NVPL TTHN FVRK TFFT LAFC DFCR KLLF QGFR CQTC GYKF HQRC STEV PLMC VNYD QLDL LFVS KFFE HHPI PQEE ASLA ETAL T |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:100 - 1:500 |
Synonyms: | NS7; B-raf; BRAF1; RAFB1; B-RAF1; BRAF-1; B-Raf |
Positive Sample: | COS-7,WCH |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Nucleus. |
Calculated MW: | 84kDa |
Observed MW: | 87kDa |
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome.
Purification Method: | Affinity purification |
Gene ID: | 673 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |