The BPHL Polyclonal Antibody (PACO08037) is a valuable tool for researchers studying BPHL, a protein enzyme involved in lipid metabolism and drug metabolism processes. This antibody, produced in rabbits, is highly specific to human samples and is suitable for use in Western blot and immunohistochemistry applications. By binding to the BPHL protein, this antibody enables the detection and analysis of BPHL expression in a variety of cell types, making it ideal for studies in pharmacology and metabolism research.
BPHL, also known as bile salt hydrolase-like protein, plays a crucial role in the hydrolysis of ester bonds within various molecules, including drugs and lipids. Its involvement in drug metabolism pathways and lipid processing makes it an intriguing target for investigating metabolic disorders, drug interactions, and toxicity mechanisms. By understanding the functions of BPHL, researchers can gain valuable insights into metabolic processes and potential therapeutic targets for related conditions.
BPHL: Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. Belongs to the AB hydrolase superfamily. Lipase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.1.-.-; HydrolaseChromosomal Location of Human Ortholog: 6p25Cellular Component: mitochondrial outer membrane; mitochondrionMolecular Function: alpha-amino-acid esterase activity; hydrolase activityBiological Process: amino acid metabolic process; response to toxin; xenobiotic metabolic process
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the serine protease family of hydrolytic enzymes which contain a serine in their active site. The encoded protein may play a role in activation of the antiviral prodrug valacyclovir. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]
