The BOK Monoclonal Antibody (CAB21196) is a specialized tool for researchers studying the BOK protein, a key regulator of apoptosis and cell death processes. This monoclonal antibody, produced through advanced cloning techniques, shows high specificity and sensitivity for detecting BOK protein in a variety of experimental setups, including Western blot, immunofluorescence, and immunoprecipitation.BOK, a member of the BCL-2 protein family, is known for its pro-apoptotic functions and its role in maintaining cellular homeostasis by eliminating damaged or unwanted cells. Dysregulation of BOK has been implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune conditions.
By using the BOK Monoclonal Antibody, researchers can investigate the expression levels, localization, and functional activity of BOK in different cell types and disease models.This antibody is an essential tool for unraveling the intricate mechanisms of cell death and survival pathways, shedding light on potential therapeutic targets for combating diseases associated with aberrant cell death processes. Its high specificity and reliability make it a valuable asset for advancing research in cell biology, cancer biology, and drug discovery.
Product Name:
BOK Monoclonal Antibody
SKU:
CAB21196
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human BOK (NP_115904.1).
The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat show that this protein has restricted expression in reproductive tissues, interacts strongly with some antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces apoptosis in transfected cells. Thus, this protein represents a proapoptotic member of the BCL2 family.
Purification Method:
Affinity purification
Gene ID:
666
Clone Number:
ARC53171
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of PC-3 cells, using BOK antibody (CAB21196) at1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:200000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
