The BOD1 Antibody (PAC019358) is a polyclonal antibody designed for research involving the BOD1 protein, which plays a critical role in cell division and proliferation. The antibody, raised in rabbits, is highly reactive with human samples and is validated for use in a variety of applications, including Western blot and immunohistochemistry.BOD1 is essential for proper cell cycle progression and genetic stability, making it a key player in the regulation of cell division and growth. Dysregulation of BOD1 has been implicated in various diseases, including cancer, making it an important target for research in oncology and cell biology.
By binding to the BOD1 protein, this antibody enables accurate detection and analysis of BOD1 levels in different cell types, providing valuable insights into its function and potential therapeutic applications. Researchers studying cell proliferation, cancer development, and genetic stability will find this antibody to be a valuable tool in their research efforts.
Antibody Name:
BOD1 Antibody (PACO19358)
Antibody SKU:
PACO19358
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human BOD1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19358(BOD1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO19358(BOD1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Bod1, a protein conserved throughout metazoans that associates with a large macromolecular complex and localizes with kinetochores and spindle poles during mitosis. Bod1-depleted cells form syntelic attachments that can oscillate and generate enough force to separate sister kinetochores, suggesting that microtubule-kinetochore interactions were intact. Releasing Bod1-depleted cells from a monastrol block increases the frequency of syntelic attachments and the number of cells displaying biorientation defects.
Synonyms:
biorientation of chromosomes in cell division 1
UniProt Protein Function:
BOD1: Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles. Belongs to the BOD1 family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 5q35.2
