BNP Monoclonal Antibody (CAB23996)
- SKU:
- CAB23996
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | BNP Monoclonal Antibody |
SKU: | CAB23996 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 35-134 of human BNP (NP_002512.1). |
Sequence: | ASDL ETSG LQEQ RNHL QGKL SELQ VEQT SLEP LQES PRPT GVWK SREV ATEG IRGH RKMV LYTL RAPR SPKM VQGS GCFG RKMD RISS SSGL GCKV LRRH |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | BNP; Iso-ANP |
Positive Sample: | Mouse brain,Mouse liver,Mouse heart,Rat heart,Rat brain |
Cellular Localization: | Secreted |
Calculated MW: | 15kDa |
Observed MW: | 15kDa |
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis.
Purification Method: | Affinity purification |
Gene ID: | 4879 |
Clone Number: | ARC62057 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |