The BNP Monoclonal Antibody is a highly specific antibody designed for research involving B-type natriuretic peptide (BNP), a key biomarker for heart failure and other cardiovascular conditions. This monoclonal antibody, produced in mice, is extremely sensitive and specific for detecting BNP in human samples, making it a valuable tool for diagnostic and research purposes.With its high affinity for BNP, this antibody is ideal for use in immunoassays, ELISA, and Western blot applications to accurately quantify and analyze BNP levels in biological samples. By targeting BNP, researchers can gain insights into cardiac function and pathology, allowing for early detection and monitoring of heart failure and related cardiovascular diseases.
BNP is a critical hormone released by the heart in response to changes in pressure and volume, serving as a marker for cardiac stress and dysfunction. The BNP Monoclonal Antibody offers researchers a reliable and efficient tool for studying the role of BNP in cardiovascular health and disease, ultimately leading to improved diagnostic and therapeutic strategies for patients at risk of heart failure.
Product Name:
BNP Monoclonal Antibody
SKU:
CAB23996
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 35-134 of human BNP (NP_002512.1).
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis.
Purification Method:
Affinity purification
Gene ID:
4879
Clone Number:
ARC62057
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using BNP Rabbit mAb (CAB23996) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
