The BNIP2 Polyclonal Antibody (CAB6282) is a vital tool for research involving the BNIP2 protein, a member of the BCL-2 family of proteins that plays a key role in apoptosis and cell survival. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the BNIP2 protein, researchers can accurately detect and analyze its expression in various cell types, making it a valuable asset in studies related to cell death pathways, cancer research, and cardiovascular disease.BNIP2, also known as BCL2/adenovirus E1B 19kDa interacting protein 2, is involved in regulating mitochondrial function and apoptotic pathways, making it a crucial target for understanding disease mechanisms and potential therapeutic interventions.
Its role in modulating cell survival and death processes highlights its importance in various cellular processes, including autophagy, hypoxia response, and cell migration.With the BNIP2 Polyclonal Antibody, researchers can delve deeper into the functions and regulatory mechanisms of BNIP2, paving the way for advancements in drug discovery and targeted therapeutics for diseases associated with dysregulation of cell death pathways.
Product Name:
BNIP2 Rabbit Polyclonal Antibody
SKU:
CAB6282
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 125-280 of human BNIP2 (NP_004321.2).
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
663
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using BNIP2 antibody (CAB6282) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
