The BMPR2 Polyclonal Antibody (CAB5666) is a valuable tool for researchers studying the BMP receptor type 2 (BMPR2) protein, a key player in the BMP signaling pathway. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the BMPR2 protein, this antibody allows for the detection and analysis of BMPR2 expression in various cell types.The BMP signaling pathway is involved in a wide range of biological processes, including cell growth, differentiation, and apoptosis. Dysregulation of this pathway, particularly through mutations in BMPR2, has been linked to various diseases, including pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia.
Therefore, studying BMPR2 expression and activity is crucial for understanding the role of BMP signaling in health and disease.With its high reactivity and specificity, the BMPR2 Polyclonal Antibody (CAB5666) is an essential tool for researchers investigating the function of BMPR2 in developmental biology, tissue homeostasis, and disease pathways. By enabling the study of BMPR2 expression and regulation, this antibody contributes to the advancement of knowledge in the field of molecular biology and potential therapeutic targets for BMP signaling-related disorders.
Product Name:
BMPR2 Rabbit Polyclonal Antibody
SKU:
CAB5666
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 27-150 of human BMPR2 (NP_001195.2).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
115kDa
Observed MW:
100kDa
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.
Purification Method:
Affinity purification
Gene ID:
659
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using BMPR2 antibody (CAB5666) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
