The BMPR1B Polyclonal Antibody (CAB17295) is a valuable tool for researchers studying BMPR1B, a member of the bone morphogenetic protein receptor family involved in various cellular processes, including cell growth, differentiation, and signaling. This antibody, generated in rabbits, exhibits high specificity and sensitivity in detecting and analyzing BMPR1B expression in human samples through methods such as Western blotting.BMPR1B, also known as bone morphogenetic protein receptor type 1B, plays a critical role in mediating the effects of BMP ligands on cell development and differentiation. Dysregulation of BMPR1B signaling has been implicated in various diseases, including skeletal disorders, cardiovascular diseases, and cancer.
By targeting BMPR1B, researchers can better understand its function and explore potential therapeutic interventions for related conditions.The BMPR1B Polyclonal Antibody is a reliable tool for investigating the expression and activity of BMPR1B in different cell types and tissues, making it an essential resource for studies in developmental biology, regenerative medicine, and cancer research. Its ability to specifically recognize BMPR1B makes it a valuable asset in furthering our understanding of the complex signaling pathways involving this receptor.
Product Name:
BMPR1B Rabbit Polyclonal Antibody
SKU:
CAB17295
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-126 of human BMPR1B (NP_001194.1).
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
658
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human mammary cancer using BMPR1B Rabbit pAb (CAB17295) at dilution of 1:200 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
