The BMPR1B Polyclonal Antibody is a powerful tool for researchers studying the BMPR1B protein, which plays a key role in bone morphogenesis and development. This antibody, produced through immunization of rabbits, exhibits high specificity and sensitivity for human samples, making it ideal for use in Western blot applications.BMPR1B, belonging to the BMP receptor family, is involved in signal transduction pathways that regulate bone formation and skeletal development. By targeting and binding to the BMPR1B protein, this antibody enables researchers to detect and analyze its expression in different cell types, facilitating investigations in developmental biology, skeletal disorders, and related fields.
Given the importance of BMPR1B in pathways controlling bone growth and remodeling, this antibody holds significant potential for advancing knowledge of skeletal development and pathologies. By unlocking the secrets of BMPR1B function, researchers can pave the way for novel therapeutic strategies targeting bone-related diseases, such as osteoporosis and skeletal dysplasias.
Product Name:
BMPR1B Polyclonal Antibody
SKU:
CAB21605
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 450-532 of human BMPR1B (NP_001243722.1).
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
658
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using BMPR1B Rabbit pAb (CAB21605) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
