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BMPR1B Rabbit Polyclonal Antibody (CAB17295)

SKU:
CAB17295
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:BMPR1B Rabbit Polyclonal Antibody
SKU:CAB17295
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-126 of human BMPR1B (NP_001194.1).
Sequence:MLLR SAGK LNVG TKKE DGES TAPT PRPK VLRC KCHH HCPE DSVN NICS TDGY CFTM IEED DSGL PVVT SGCL GLEG SDFQ CRDT PIPH QRRS IECC TERN ECNK DLHP TLPP LKNR DFVD GPIH HR
Tested Applications:IHC-P IF/ICC ELISA
Recommended Dilution:IHC-P,1:50 - 1:200 IF/ICC,1:500 - 1:1000
Synonyms:ALK6; AMD3; AMDD; BDA2; ALK-6; BDA1D; CDw293; BMPR1B
Conjugate:Unconjugated
Cellular Localization:Membrane, Single-pass type I membrane protein.
Calculated MW:57kDa
Observed MW:Refer to figures

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene.

Purification Method:Affinity purification
Gene ID:658
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageImmunohistochemistry analysis of paraffin-embedded human mammary cancer using BMPR1B Rabbit pAb (CAB17295) at dilution of 1:200 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.

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