The BMPR1A Polyclonal Antibody (CAB1816) is a crucial tool for researchers studying the bone morphogenetic protein receptor type 1A (BMPR1A), a key molecule involved in cellular signaling pathways and development. This antibody, generated in rabbits, exhibits high specificity and reactivity with human samples, making it a valuable asset for Western blot applications. By binding to the BMPR1A protein, this antibody enables precise detection and analysis in various cell types, offering insights into the role of BMPR1A in physiological processes and disease states.BMPR1A plays a pivotal role in mediating the effects of bone morphogenetic proteins, which are essential for embryonic development, tissue differentiation, and bone formation.
Dysregulation of the BMPR1A signaling pathway has been implicated in various diseases, including skeletal disorders, cardiovascular conditions, and cancer. Research into BMPR1A function is vital for uncovering potential therapeutic targets and strategies for treating these disorders.Overall, the BMPR1A Polyclonal Antibody (CAB1816) provides researchers with a reliable tool for investigating the functions and mechanisms of BMPR1A, offering new opportunities for advancing our understanding of cellular signaling pathways and their implications for human health.
Product Name:
BMPR1A Rabbit Polyclonal Antibody
SKU:
CAB1816
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 24-200 of human BMPR1A (NP_004320.2).
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
Purification Method:
Affinity purification
Gene ID:
657
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using BMPR1A Rabbit pAb (CAB1816) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
