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BMPER Antibody (PACO58344)

SKU:
PACO58344
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€359

Description

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BMPER Antibody (PACO58344)

The BMPER polyclonal antibody (PAC058344) is a valuable tool for researchers studying BMPER, a protein involved in bone morphogenetic protein (BMP) signaling pathways. This antibody, produced in rabbits, is highly specific for BMPER and is validated for use in Western blot applications with human samples.BMPER is a key regulator of BMP signaling, playing a critical role in various physiological processes such as bone development, angiogenesis, and tissue homeostasis. Dysregulation of BMPER expression has been implicated in various diseases, including cancer, cardiovascular disorders, and skeletal abnormalities.

By targeting BMPER with this antibody, researchers can assess BMPER expression levels and study its function in different cell types, providing valuable insights into the molecular mechanisms underlying BMP signaling pathways.Overall, the BMPER polyclonal antibody is a reliable tool for researchers interested in investigating the role of BMPER in development, disease, and therapeutic interventions. Its high specificity and sensitivity make it a valuable asset for studies in molecular biology, cell biology, and biomedicine.

Antibody Name:BMPER Antibody (PACO58344)
Antibody SKU:PACO58344
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:Human
Immunogen:Recombinant Human BMP-binding endothelial regulator protein (271-418AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageIHC image of PACO58344 diluted at 1:200 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.
Synonyms:BMP-binding endothelial regulator protein (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2), BMPER, KIAA1965
UniProt Protein Function:BMPER: Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes. Defects in BMPER are the cause of diaphanospondylodysostosis (DSD). A rare, recessively inherited, perinatal lethal skeletal disorder. The primary skeletal characteristics of the phenotype include a small chest, abnormal vertebral segmentation, and posterior rib gaps containing incompletely differentiated mesenchymal tissue. Consistent craniofacial features include ocular hypertelorism, epicanthal folds, a depressed nasal bridge with a short nose, and low-set ears. The most commonly described extraskeletal finding is nephroblastomatosis with cystic kidneys, but other visceral findings have been described in some cases.Protein type: Secreted, signal peptide; Inhibitor; SecretedChromosomal Location of Human Ortholog: 7p14.3Cellular Component: extracellular spaceBiological Process: blood vessel endothelial cell proliferation during sprouting angiogenesis; endothelial cell activation; negative regulation of BMP signaling pathwayDisease: Diaphanospondylodysostosis
UniProt Protein Details:
NCBI Summary:This gene encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. Mutations in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis. [provided by RefSeq, Dec 2011]
UniProt Code:Q8N8U9
NCBI GenInfo Identifier:116241270
NCBI Gene ID:168667
NCBI Accession:Q8N8U9.3
UniProt Secondary Accession:Q8N8U9,Q8TF36, A8K1P8
UniProt Related Accession:Q8N8U9
Molecular Weight:75,997 Da
NCBI Full Name:BMP-binding endothelial regulator protein
NCBI Synonym Full Names:BMP binding endothelial regulator
NCBI Official Symbol:BMPER  
NCBI Official Synonym Symbols:CV2; CV-2; CRIM3  
NCBI Protein Information:BMP-binding endothelial regulator protein
UniProt Protein Name:BMP-binding endothelial regulator protein
UniProt Synonym Protein Names:Bone morphogenetic protein-binding endothelial cell precursor-derived regulator; Protein crossveinless-2; hCV2
Protein Family:BMP-binding endothelial regulator protein
UniProt Gene Name:BMPER  
UniProt Entry Name:BMPER_HUMAN
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