The BMP8B Antibody (PAC02206) is a crucial tool for researchers studying bone morphogenetic protein 8B (BMP8B), a member of the TGF-beta superfamily known for its role in bone and cartilage development. This polyclonal antibody, produced in rabbits, is highly specific to human samples and has been validated for use in various research applications, including Western blotting.BMP8B is a key regulator of skeletal development and homeostasis, making it a valuable target for studies in musculoskeletal research and regenerative medicine. By binding to BMP8B protein, this antibody enables precise detection and analysis of BMP8B expression in a variety of cell types, providing insights into its functions and mechanisms of action.
With its ability to facilitate the investigation of BMP8B signaling pathways, this antibody is essential for researchers seeking to understand the molecular basis of bone formation and remodeling. By uncovering the roles of BMP8B in skeletal health and disease, this antibody contributes to advancements in the fields of orthopedics, osteology, and tissue engineering.
Antibody Name:
BMP8B Antibody (PACO22206)
Antibody SKU:
PACO22206
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human BMP8B.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from 293 cells and A549 cells, using BMP8B antibody.
Background:
Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis By similarity.
Synonyms:
Bone morphogenetic protein 8B; BMP-8B; BMP-8; BMP8; Osteogenic protein 2
UniProt Protein Function:
BMP8B: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Belongs to the TGF-beta family.Protein type: Secreted; Secreted, signal peptide; CytokineChromosomal Location of Human Ortholog: 1p35-p32Cellular Component: extracellular spaceMolecular Function: cytokine activity; growth factor activity; transforming growth factor beta receptor bindingBiological Process: BMP signaling pathway; cartilage development; cell development; growth; ossification; regulation of apoptosis; regulation of MAPKKK cascade; skeletal development
