The BMP8A Polyclonal Antibody (PAC02394) is a valuable tool for researchers studying BMP8A, a protein belonging to the bone morphogenetic protein family that plays a key role in various physiological processes. This rabbit-derived antibody has been validated for use in Western blot applications and is highly reactive with human samples.BMP8A is known to regulate energy balance, thermogenesis, and metabolism, making it a promising target for research into obesity, diabetes, and other metabolic disorders.
By binding specifically to the BMP8A protein, this antibody allows for accurate detection and analysis in a variety of cell types, enabling researchers to further explore the functions and pathways associated with BMP8A.With its ability to support studies in metabolic research and potential implications for therapeutic interventions, the BMP8A Polyclonal Antibody is a valuable tool for scientists interested in understanding the role of BMP8A in health and disease.
Synthesized peptide derived from C-terminal of human BMP8A.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from COLO cells, using BMP8A antibody.
Immunofluorescence analysis of A549 cells, using BMP8A antibody.
Background:
Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis By similarity. Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT.
Synonyms:
Bone morphogenetic protein 8A [Precursor]; BMP-8A;
UniProt Protein Function:
BMP8A: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Belongs to the TGF-beta family.Protein type: Cytokine; Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 1p34.3Cellular Component: extracellular spaceMolecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor bindingBiological Process: BMP signaling pathway; regulation of apoptosis; ossification; diet induced thermogenesis; regulation of MAPKKK cascade; cartilage development; cell development; growth; negative regulation of insulin secretion
