The BMP8A Polyclonal Antibody (PACO06293) is a valuable tool for researchers studying BMP8A, a member of the bone morphogenetic protein (BMP) family known for its role in regulating metabolism and energy balance. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.BMP8A is a secreted protein that has been implicated in various physiological processes, including thermogenesis, brown adipose tissue activation, and insulin sensitivity. Research suggests that BMP8A may play a role in metabolic disorders, such as obesity and diabetes, making it an attractive target for investigating potential therapeutic interventions.
By utilizing the BMP8A Polyclonal Antibody, researchers can effectively detect and analyze BMP8A expression in a variety of cell types and tissues, providing valuable insights into the molecular mechanisms underlying metabolic regulation. This antibody is an essential tool for studies in metabolic research, obesity, diabetes, and related diseases, offering new possibilities for understanding and targeting BMP8A in the context of human health.
Synthesized peptide derived from the C-terminal region of human BMP-8A.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of 293 Jurkat A549 cells using BMP-8A Polyclonal Antibody.
Western Blot analysis of COLO205 cells using BMP-8A Polyclonal Antibody.
Synonyms:
BMP8A; Bone morphogenetic protein 8A; BMP-8A
UniProt Protein Function:
BMP8A: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Belongs to the TGF-beta family.Protein type: Cytokine; Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 1p34.3Cellular Component: extracellular spaceMolecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor bindingBiological Process: BMP signaling pathway; regulation of apoptosis; ossification; diet induced thermogenesis; regulation of MAPKKK cascade; cartilage development; cell development; growth; negative regulation of insulin secretion