The BMP7 Polyclonal Antibody (CAB0697) is a valuable tool for researchers studying Bone Morphogenetic Protein 7 (BMP7), a critical regulator of bone and cartilage development. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for Western blot applications.BMP7 is a member of the TGF-beta superfamily and plays a crucial role in promoting bone formation and regulating skeletal development. Dysregulation of BMP7 signaling has been linked to various skeletal disorders, making it a target of interest in orthopedic research and regenerative medicine.
By binding specifically to BMP7 protein, this antibody allows for the precise detection and analysis of BMP7 in various cell types, providing valuable insights into its function and potential therapeutic applications. Researchers in the fields of orthopedics, bone biology, and regenerative medicine will find this antibody indispensable for understanding the role of BMP7 in skeletal development and disease.
Product Name:
BMP7 Rabbit Polyclonal Antibody
SKU:
CAB0697
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 70-251 of BMP7 (NP_001710.1).
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients.
Purification Method:
Affinity purification
Gene ID:
655
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using BMP7 Rabbit pAb (CAB0697) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
