The BMP6 Polyclonal Antibody (CAB8333) is a valuable tool for researchers studying Bone Morphogenetic Protein 6 (BMP6), a member of the TGF-beta superfamily that plays a key role in bone and cartilage formation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.BMP6 is known for its involvement in regulating cellular growth, differentiation, and development, making it a crucial target for research in bone biology, tissue regeneration, and developmental biology.
The BMP6 Polyclonal Antibody allows for the detection and analysis of BMP6 protein levels in various cell types, enabling researchers to explore its functions and mechanisms of action.With its ability to specifically bind to BMP6, this antibody is an essential tool for studies in regenerative medicine, musculoskeletal disorders, and skeletal diseases. By understanding the role of BMP6 in these contexts, researchers can potentially develop novel therapeutics and interventions for conditions related to bone and cartilage health.
Product Name:
BMP6 Rabbit Polyclonal Antibody
SKU:
CAB8333
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 375-513 of human BMP6 (NP_001709.1).
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients.
Purification Method:
Affinity purification
Gene ID:
654
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using BMP6 Antibody (CAB8333) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
