The BMP6 Polyclonal Antibody (CAB15648) is a valuable tool for researchers studying BMP6, a member of the bone morphogenetic protein family that plays a crucial role in bone and cartilage development. This antibody, generated in rabbits, is highly specific to human samples and is suitable for use in Western blot applications. It targets the BMP6 protein, allowing for easy detection and analysis in a variety of cell types, making it an ideal option for investigations in developmental biology and regenerative medicine.BMP6 is involved in various biological processes, including cell differentiation, proliferation, and apoptosis, making it a key player in tissue development and homeostasis. Dysregulation of BMP6 signaling has been linked to skeletal disorders, such as osteoporosis and osteoarthritis, highlighting the importance of studying this protein in the context of musculoskeletal health.
With its ability to accurately detect BMP6 levels, this antibody is essential for unraveling the complex mechanisms underlying bone formation and repair.Overall, the BMP6 Polyclonal Antibody is a reliable tool for researchers seeking to deepen their understanding of BMP6 function and its implications in skeletal biology. By elucidating the role of BMP6 in disease pathology and tissue regeneration, this antibody paves the way for potential therapeutic interventions targeting BMP6 signaling pathways.
Product Name:
BMP6 Rabbit Polyclonal Antibody
SKU:
CAB15648
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 375-513 of human BMP6 (NP_001709.1).
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients.
Purification Method:
Affinity purification
Gene ID:
654
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of U2OS cells using BMP6 Rabbit pAb (CAB15648) at dilution of 1:100. Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
