The BMP4 Polyclonal Antibody (CAB11315) is a valuable tool for researchers studying bone morphogenetic protein 4 (BMP4), a protein that plays a key role in bone and cartilage development, as well as in various other biological processes. This antibody, generated in rabbits, is highly specific for detecting BMP4 in human samples and is ideal for use in Western blot applications. By targeting the BMP4 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it a valuable asset for studies in developmental biology, regenerative medicine, and tissue engineering.BMP4, a member of the TGF-β superfamily, is a potent regulator of cell growth, differentiation, and apoptosis, and is involved in embryogenesis, organogenesis, and tissue repair.
Dysregulation of BMP4 signaling has been implicated in a range of diseases, including skeletal disorders, cardiovascular diseases, and cancers. By understanding the function and regulation of BMP4, researchers can gain insights into the underlying mechanisms of these pathologies and potentially develop therapeutic interventions targeting BMP4 signaling pathways.Overall, the BMP4 Polyclonal Antibody (CAB11315) is a reliable tool for investigating the role of BMP4 in various biological processes and disease conditions, providing valuable data for advancing our understanding of BMP4 biology and its potential therapeutic applications.
Product Name:
BMP4 Rabbit Polyclonal Antibody
SKU:
CAB11315
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human BMP4 (NP_001193.2).
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers.
Purification Method:
Affinity purification
Gene ID:
652
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using BMP4 Rabbit pAb (CAB11315) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 45s.
