The BMP2 Polyclonal Antibody (CAB14708) is a valuable tool for researchers studying bone morphogenetic protein 2 (BMP2), a key player in osteogenesis and bone formation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to BMP2, researchers can accurately detect and analyze the protein in various cell types, making it an essential component of studies in bone biology and regenerative medicine.
BMP2 is a potent signaling molecule that plays a crucial role in the development and maintenance of bone and cartilage. Its involvement in osteogenic differentiation and bone regeneration makes it a promising target for therapeutic interventions in bone-related disorders such as osteoporosis and bone fractures. By elucidating the mechanisms underlying BMP2 function, researchers can pave the way for innovative treatments that enhance bone healing and regeneration.
Product Name:
BMP2 Rabbit Polyclonal Antibody
SKU:
CAB14708
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human BMP2 (NP_001191.1).
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients.
Purification Method:
Affinity purification
Gene ID:
650
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of Rat ovary, using BMP2 antibody (CAB14708) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
