The BMP2 Polyclonal Antibody (CAB12781) is a valuable tool for researchers studying bone morphogenetic protein 2 (BMP2), a key signaling molecule involved in bone and cartilage formation. This antibody, produced in rabbits, is highly specific for detecting BMP2 in human samples and is validated for use in Western blot applications.BMP2 plays a crucial role in various cellular processes, including cell differentiation, proliferation, and apoptosis. Its dysregulation has been linked to bone disorders, such as osteoporosis and osteoarthritis, as well as cancer progression.
By targeting BMP2 with this antibody, researchers can explore its function in different cell types and investigate its role in various diseases.Overall, the BMP2 Polyclonal Antibody is a reliable tool for scientists interested in unraveling the molecular mechanisms mediated by BMP2 and its potential as a therapeutic target in bone-related disorders and cancer.
Product Name:
BMP2 Rabbit Polyclonal Antibody
SKU:
CAB12781
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human BMP2 (NP_001191.1).
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients.
Purification Method:
Affinity purification
Gene ID:
650
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using BMP2 Antibody (CAB12781) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 30s.
