The BMP15 Rabbit Monoclonal Antibody (CAB4148) is a highly specific and sensitive tool for researchers studying Bone Morphogenetic Protein 15 (BMP15), a crucial member of the transforming growth factor beta (TGF-β) superfamily. BMP15 is known for its involvement in ovarian function and fertility, particularly in regulating folliculogenesis and oocyte development.This monoclonal antibody, generated in rabbits, shows exceptional reactivity with human samples and is validated for use in various applications, including Western blot and immunohistochemistry. Its ability to bind specifically to the BMP15 protein allows for accurate detection and analysis in different cell types and tissue samples, making it an essential tool for researchers in reproductive biology and infertility studies.
Understanding the role of BMP15 in ovarian function is essential for advancing knowledge of reproductive biology and developing interventions for infertility and reproductive disorders. The BMP15 Rabbit Monoclonal Antibody (CAB4148) provides researchers with a reliable and effective means to investigate the functions of BMP15 and explore its potential as a therapeutic target in fertility treatments.
Product Name:
BMP15 Rabbit Monoclonal Antibody
SKU:
CAB4148
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 293-392 of human BMP15 (O95972).
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure.
Purification Method:
Affinity purification
Gene ID:
9210
Clone Number:
ARC0907
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using BMP15 Rabbit mAb (CAB4148) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
