The BMP10 Polyclonal Antibody (CAB15010) is a crucial tool for researchers studying bone morphogenetic protein 10 (BMP10), a member of the TGF-beta superfamily known for its role in cardiovascular development and angiogenesis. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting BMP10 in human samples, making it a reliable choice for Western blot experiments.BMP10 is essential for proper heart formation and vascular development, making it a promising target for research in cardiology and vascular biology. By binding to BMP10, this antibody enables precise identification and quantification of the protein in a variety of cell types, providing valuable insights into its function and potential therapeutic applications.
Researchers exploring cardiac development, vascular biology, or BMP signaling pathways can benefit from the BMP10 Polyclonal Antibody, as it offers accurate and reproducible results for their experiments. Its utility in studying BMP10 makes it an indispensable tool in the quest to unravel the molecular mechanisms underlying cardiovascular diseases and angiogenesis.
Product Name:
BMP10 Rabbit Polyclonal Antibody
SKU:
CAB15010
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-316 of human BMP10 (NP_055297.1).
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation.
Purification Method:
Affinity purification
Gene ID:
27302
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from rat heart, using BMP10 Rabbit pAb (CAB15010) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
