The BMI1 Rabbit Monoclonal Antibody (CAB17914) is a valuable tool for researchers studying BMI1, a protein involved in the regulation of stem cell self-renewal and differentiation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the BMI1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in stem cell biology, cancer research, and developmental biology.BMI1 is a critical regulator of cell proliferation and differentiation, playing a key role in maintaining the self-renewal capacity of stem cells.
Dysregulation of BMI1 has been implicated in various diseases, including cancer and developmental disorders. By studying the function of BMI1 using this antibody, researchers can gain valuable insights into how this protein contributes to the development and progression of these conditions.Overall, the BMI1 Rabbit Monoclonal Antibody (CAB17914) is a reliable tool for exploring the role of BMI1 in cellular processes and disease pathways, ultimately paving the way for the development of novel therapeutic strategies aimed at targeting BMI1-related mechanisms.
Product Name:
Bmi1 Rabbit Monoclonal Antibody
SKU:
CAB17914
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 227-326 of human Bmi1 (P35226).
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene.
Purification Method:
Affinity purification
Gene ID:
648
Clone Number:
ARC0376
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Bmi1 antibody (CAB17914) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
