Bmi1 Rabbit Polyclonal Antibody (CAB13472)
- SKU:
- CAB13472
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | Bmi1 Rabbit Polyclonal Antibody |
SKU: | CAB13472 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-326 of human Bmi1 (NP_005171.4). |
Sequence: | EDKR IITD DEII SLSI EFFD QNRL DRKV NKDK EKSK EEVN DKRY LRCP AAMT VMHL RKFL RSKM DIPN TFQI DVMY EEEP LKDY YTLM DIAY IYTW RRNG PLPL KYRV RPTC KRMK ISHQ RDGL TNAG ELES DSGS DKAN SPAG GIPS TSSC LPSP STPV QSPH PQFP HISS TMNG TSNS PSGN HQSS FANR PRKS SVNG SSAT SSG |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | PCGF4; RNF51; FLVI2/BMI1; flvi-2/bmi-1; Bmi1 |
Positive Sample: | U-937 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 37kDa |
Observed MW: | 41kDa |
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene.
Purification Method: | Affinity purification |
Gene ID: | 648 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |