The BMI1 Polyclonal Antibody (CAB13472) is a valuable tool for researchers studying BMI1, a crucial protein involved in stem cell self-renewal and cancer progression. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting BMI1 in human samples, making it perfect for use in Western blotting applications.BMI1 is known for its role in maintaining stem cell populations and promoting tumor growth by regulating cell proliferation and senescence. Research has shown that BMI1 expression is dysregulated in various cancers, making it a potential target for anti-cancer therapies.
By using the BMI1 Polyclonal Antibody, researchers can investigate the expression and function of BMI1 in different cell types and explore its potential as a prognostic marker or therapeutic target in cancer research.Overall, the BMI1 Polyclonal Antibody is a reliable tool for studying the function of BMI1 in stem cells and cancer, providing valuable insights into the molecular mechanisms underlying tumorigenesis and potential therapeutic strategies.
Product Name:
Bmi1 Rabbit Polyclonal Antibody
SKU:
CAB13472
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 120-326 of human Bmi1 (NP_005171.4).
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene.
Purification Method:
Affinity purification
Gene ID:
648
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of U-937 cells, using Bmi1 antibody (CAB13472) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 30s.
