Bmi1 Rabbit Polyclonal Antibody (CAB0211)
- SKU:
- CAB0211
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | Bmi1 Rabbit Polyclonal Antibody |
SKU: | CAB0211 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Bmi1 (NP_005171.4). |
Sequence: | LKDY YTLM DIAY IYTW RRNG PLPL KYRV RPTC KRMK ISHQ RDGL TNAG ELES DSGS DKAN SPAG GIPS TSSC LPSP STPV QSPH PQFP HISS TMNG TSNS P |
Tested Applications: | WB IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | PCGF4; RNF51; FLVI2/BMI1; flvi-2/bmi-1; Bmi1 |
Positive Sample: | HeLa,A-549,K-562,Mouse heart,Mouse thymus,Rat thymus,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 37kDa |
Observed MW: | 43kDa |
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene.
Purification Method: | Affinity purification |
Gene ID: | 648 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |