The BMF Polyclonal Antibody (CAB5796) is a vital tool for researchers studying the apoptotic activator BMF, a protein involved in the regulation of programmed cell death. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it an excellent choice for Western blot applications. By binding specifically to the BMF protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in the fields of cell biology and cancer research.
BMF, also referred to as Bcl-2-modifying factor, is a key player in the apoptosis pathway, influencing cell survival and death decisions. Understanding the functions and mechanisms of BMF is essential for unraveling the complexities of cellular processes and for developing targeted therapies for diseases such as cancer. By studying BMF and its interactions, researchers may uncover new treatment strategies and potential therapeutic targets for combating various pathologies.
Product Name:
BMF Rabbit Polyclonal Antibody
SKU:
CAB5796
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-184 of human BMF (NP_277038.1).
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
90427
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using BMF antibody (CAB5796) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 90s.
