The BMAL1 Rabbit Monoclonal Antibody (CAB4714) is a cutting-edge tool for researchers studying the circadian clock and its impact on health and disease. This antibody is specifically designed to target BMAL1, a key transcription factor involved in the regulation of circadian rhythm and biological processes. Raised in rabbits, this monoclonal antibody is highly specific and exhibits minimal cross-reactivity, ensuring accurate and reliable results in experiments. It has been rigorously validated for use in various applications, including Western blotting, immunofluorescence, and immunohistochemistry, making it versatile for a wide range of research needs.
By targeting BMAL1, researchers can gain insights into the mechanisms underlying circadian rhythm regulation and its implications for various physiological processes, such as metabolism, immunity, and behavior. This antibody is an invaluable tool for studies in chronobiology, sleep disorders, metabolic diseases, and other areas where circadian disruption plays a role. Overall, the BMAL1 Rabbit Monoclonal Antibody (CAB4714) offers researchers a high-quality and specific reagent to further explore the fascinating world of circadian biology and its impact on human health.
Product Name:
BMAL1 Rabbit Monoclonal Antibody
SKU:
CAB4714
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 500-600 of human BMAL1 (O00327).
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. The protein regulates interferon-stimulated gene expression and is an important factor in viral infection, including COVID-19.
Purification Method:
Affinity purification
Gene ID:
406
Clone Number:
ARC1101
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using BMAL1 Rabbit mAb (CAB4714) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
