The BLOC1S5 Antibody (PAC038606) is a powerful tool for researchers studying BLOC1S5, a key protein involved in trafficking and sorting of intracellular vesicles. This polyclonal antibody is produced in rabbits and is highly reactive with human samples, making it a valuable tool for studies in cell biology and molecular biology.BLOC1S5 is a subunit of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), which is essential for the formation of specialized organelles such as melanosomes and platelet dense granules. Mutations in BLOC-1 subunits have been linked to Hermansky-Pudlak syndrome, a rare genetic disorder characterized by albinism and bleeding diathesis.By targeting BLOC1S5, researchers can gain insights into the molecular mechanisms underlying organelle biogenesis and the pathogenesis of related disorders.
The BLOC1S5 Antibody allows for the specific detection of BLOC1S5 protein in various cell types, facilitating detailed analysis and furthering our understanding of intracellular trafficking pathways.This antibody is validated for use in Western blot applications and is a valuable tool for investigating the functions of BLOC1S5 in normal cellular processes and disease states. By studying BLOC1S5, researchers can uncover new therapeutic targets and develop potential treatments for disorders associated with organelle dysfunction.
Antibody Name:
BLOC1S5 Antibody (PACO38606)
Antibody SKU:
PACO38606
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Biogenesis of lysosome-related organelles complex 1 subunit 5 protein (2-187AA)
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO38606 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human melanoma using PACO38606 at dilution of 1:100.
Background:
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking.
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking.
UniProt Protein Details:
NCBI Summary:
This gene encodes a component of BLOC-1 (biogenesis of lysosome-related organelles complex 1). Components of this complex are involved in the biogenesis of organelles such as melanosomes and platelet-dense granules. A mouse model for Hermansky-Pudlak Syndrome is mutated in the murine version of this gene. Alternative splicing results in multiple transcript variants. Read-through transcription exists between this gene and the upstream EEF1E1 (eukaryotic translation elongation factor 1 epsilon 1) gene, as well as with the downstream TXNDC5 (thioredoxin domain containing 5) gene. [provided by RefSeq, Dec 2010]
