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BLNK Antibody (PACO08022)

SKU:
PACO08022
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459
Frequently bought together:

Description

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BLNK Antibody (PACO08022)

The BLNK Antibody (PACO08022) is a powerful tool for researchers studying the B cell linker protein (BLNK), a critical adapter molecule involved in B cell receptor signaling. This polyclonal antibody is produced by immunizing rabbits and has high specificity for BLNK in human samples. Validated for use in Western blotting, the BLNK Antibody binds to BLNK with high affinity, enabling precise detection and analysis in various cell types.BLNK plays a crucial role in transmitting signals from the B cell receptor to downstream signaling pathways, ultimately regulating various immune responses.

Dysregulation of BLNK expression or function has been implicated in numerous diseases, including autoimmune disorders, immunodeficiency diseases, and certain types of leukemia. Therefore, studying BLNK using the PACO08022 Antibody can provide valuable insights into the molecular mechanisms underlying these conditions and potentially lead to the development of novel therapeutic strategies targeting BLNK.

Antibody Name:BLNK Antibody (PACO08022)
Antibody SKU:PACO08022
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human BLNK
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity Purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:B-cell linker;BLNK;BASH;BLNK-S;LY57;MGC111051;SLP-65;SLP65 ;
UniProt Protein Function:BLNK: an adaptor protein that bridges the B-cell receptor-associated kinases (BCR) with a multitude of signaling pathways, regulating biologic outcomes of B-cell function and development. Plays an important role in BCR-mediated PLCG1 activation and Ca(2 ) mobilization. Does not seem to be not required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Its phosphorylation is required for both Ca(2 ) and MAPK signaling pathways. Defects in BLNK are the cause of hypoglobulinemia and absent B-cells.It has tumor supressor activity that is lost in many cases of childhood pre-B acute lymphoblastic leukemia (ALL). Two alternatively spliced isoforms have been described; these are differentially involved in activation and apoptosis of B lymphocytes.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 10q23.2-q23.33

Cellular Component: cytoplasm; cytosol; plasma membrane

Molecular Function:protein binding; SH3/SH2 adaptor activity; transmembrane receptor protein tyrosine kinase adaptor protein activity

Biological Process: humoral immune response; inflammatory response

Disease: Agammaglobulinemia 4, Autosomal Recessive

NCBI Summary:This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
UniProt Code:Q8WV28
NCBI GenInfo Identifier:82592659
NCBI Gene ID:29760
NCBI Accession:Q8WV28.2
UniProt Secondary Accession:Q8WV28,O75498, O75499, Q2MD49,
UniProt Related Accession:Q8WV28
Molecular Weight:44,451 Da
NCBI Full Name:B-cell linker protein
NCBI Synonym Full Names:B-cell linker
NCBI Official Symbol:BLNK  
NCBI Official Synonym Symbols:bca; AGM4; BASH; LY57; SLP65; BLNK-S; SLP-65  
NCBI Protein Information:B-cell linker protein
UniProt Protein Name:B-cell linker protein
UniProt Synonym Protein Names:B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Cytoplasmic adapter protein; Src homology 2 domain-containing leukocyte protein of 65 kDa; SLP-65
Protein Family:B-cell linker protein
UniProt Gene Name:BLNK  
UniProt Entry Name:BLNK_HUMAN

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