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BLNK Antibody (PACO00469)

SKU:
PACO00469
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

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BLNK Antibody (PACO00469)

The BLNK Antibody (PAC00469) is a valuable tool for researchers studying B cell receptor signaling pathways. This polyclonal antibody, generated in rabbits, specifically targets the BLNK protein, which plays a crucial role in the activation of B cells. It is highly reactive with human samples and has been validated for use in Western blot applications.BLNK, also known as B cell linker protein, is essential for transmitting signals from the B cell receptor to downstream signaling molecules, ultimately leading to B cell activation and antibody production.

Dysregulation of BLNK signaling has been linked to various autoimmune diseases and B cell malignancies, making it a key target for therapeutic interventions.By utilizing the BLNK Antibody in their research, scientists can gain insights into the mechanisms underlying B cell activation and differentiation, as well as identify potential targets for novel therapies aimed at modulating immune responses. This antibody is a valuable tool for studies in immunology, oncology, and autoimmune disorders.

Antibody Name:BLNK Antibody
Antibody SKU:PACO00469
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from human BLNK around the non-phosphorylation site of Y96.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:BLNK; BASH; SLP65; B-cell linker protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Cytoplasmic adapter protein; Src homology 2 domain-containing leukocyte protein of 65 kDa;
UniProt Protein Function:BLNK: an adaptor protein that bridges the B-cell receptor-associated kinases (BCR) with a multitude of signaling pathways, regulating biologic outcomes of B-cell function and development. Plays an important role in BCR-mediated PLCG1 activation and Ca(2 ) mobilization. Does not seem to be not required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Its phosphorylation is required for both Ca(2 ) and MAPK signaling pathways. Defects in BLNK are the cause of hypoglobulinemia and absent B-cells.It has tumor supressor activity that is lost in many cases of childhood pre-B acute lymphoblastic leukemia (ALL). Two alternatively spliced isoforms have been described; these are differentially involved in activation and apoptosis of B lymphocytes.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 10q23.2-q23.33

Cellular Component: cytoplasm; cytosol; plasma membrane

Molecular Function:protein binding; SH3/SH2 adaptor activity; transmembrane receptor protein tyrosine kinase adaptor protein activity

Biological Process: humoral immune response; inflammatory response

Disease: Agammaglobulinemia 4, Autosomal Recessive

NCBI Summary:This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
UniProt Code:Q8WV28
NCBI GenInfo Identifier:82592659
NCBI Gene ID:29760
NCBI Accession:Q8WV28.2
UniProt Secondary Accession:Q8WV28,O75498, O75499, Q2MD49,
UniProt Related Accession:Q8WV28
Molecular Weight:44,451 Da
NCBI Full Name:B-cell linker protein
NCBI Synonym Full Names:B-cell linker
NCBI Official Symbol:BLNK  
NCBI Official Synonym Symbols:bca; AGM4; BASH; LY57; SLP65; BLNK-S; SLP-65  
NCBI Protein Information:B-cell linker protein
UniProt Protein Name:B-cell linker protein
UniProt Synonym Protein Names:B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Cytoplasmic adapter protein; Src homology 2 domain-containing leukocyte protein of 65 kDa; SLP-65
Protein Family:B-cell linker protein
UniProt Gene Name:BLNK  
UniProt Entry Name:BLNK_HUMAN

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