The BLCAP Polyclonal Antibody (PACO03370) is a valuable tool for researchers studying BLCAP, a protein involved in various cellular processes, including cell proliferation and apoptosis. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in applications such as Western blotting.BLCAP, also known as Bladder Cancer Associated Protein, has been implicated in cancer development and progression, making it a promising target for cancer research. By binding specifically to the BLCAP protein, this antibody enables precise detection and analysis in different cell types, facilitating investigations into the role of BLCAP in cancer biology.
The ability to study BLCAP's functions and interactions can provide valuable insights into its potential as a biomarker or therapeutic target in cancer treatment. Researchers can use this antibody to explore the mechanisms underlying BLCAP's involvement in tumorigenesis and to develop targeted therapies that exploit its role in cancer progression.
Antibody Name:
BLCAP Antibody
Antibody SKU:
PACO03370
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
IF:1:200-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human Bc10.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
BLCAP: May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B. Belongs to the BLCAP family.Protein type: Membrane protein, integral; Apoptosis; Membrane protein, multi-pass; Cell cycle regulationChromosomal Location of Human Ortholog: 20q11.23Cellular Component: integral to membraneMolecular Function: protein bindingBiological Process: apoptotic nuclear changes; cell cycle
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein that reduces cell growth by stimulating apoptosis. Alternative splicing and the use of alternative promoters result in multiple transcript variants encoding the same protein. This gene is imprinted in brain where different transcript variants are expressed from each parental allele. Transcript variants initiating from the upstream promoter are expressed preferentially from the maternal allele, while transcript variants initiating downstream of the interspersed NNAT gene (GeneID:4826) are expressed from the paternal allele. Transcripts at this locus may also undergo A to I editing, resulting in amino acid changes at three positions in the N-terminus of the protein. [provided by RefSeq, Nov 2015]
