| UniProt Protein Function: | BIRC6: Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Homodimer. Binds the activated, processed forms of CASP3, CASP6, CASP7 and CASP9. Interacts with RNF41, DIABLO/SMAC, HTRA2, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8. Expressed in brain cancer cells. Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.19; EC 6.3.2.- Chromosomal Location of Human Ortholog: 2p22.3 Cellular Component: spindle pole; membrane; microtubule organizing center; trans-Golgi network; midbody; endosome Molecular Function:protein binding; ubiquitin-protein ligase activity; cysteine protease inhibitor activity; ligase activity Biological Process: mitosis; apoptosis; cell division; positive regulation of cell proliferation; protein ubiquitination; regulation of cytokinesis; protein amino acid phosphorylation; negative regulation of apoptosis; regulation of cell proliferation |
| NCBI Summary: | This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NR09 |
| NCBI GenInfo Identifier: | 153792694 |
| NCBI Gene ID: | 57448 |
| NCBI Accession: | NP_057336 |
| UniProt Secondary Accession: | Q9NR09,Q9ULD1, |
| UniProt Related Accession: | Q9NR09 |
| Molecular Weight: | 530,255 Da |
| NCBI Full Name: | baculoviral IAP repeat-containing protein 6 |
| NCBI Synonym Full Names: | baculoviral IAP repeat containing 6 |
| NCBI Official Symbol: | BIRC6Â Â |
| NCBI Official Synonym Symbols: | BRUCE; APOLLONÂ Â |
| NCBI Protein Information: | baculoviral IAP repeat-containing protein 6 |
| UniProt Protein Name: | Baculoviral IAP repeat-containing protein 6 |
| UniProt Synonym Protein Names: | BIR repeat-containing ubiquitin-conjugating enzyme; BRUCE; Ubiquitin-conjugating BIR domain enzyme apollon; APOLLON |
| Protein Family: | GTP:AMP phosphotransferase |
| UniProt Gene Name: | BIRC6Â Â |
| UniProt Entry Name: | BIRC6_HUMAN |
