The BIRC6 Polyclonal Antibody (PAC018943) is a valuable tool for researchers studying BIRC6, a protein belonging to the inhibitor of apoptosis (IAP) family. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the BIRC6 protein, it allows for the detection and analysis of BIRC6 in a variety of cell types, making it an essential component in studies related to apoptosis, cancer, and cell survival pathways.BIRC6, also known as BRUCE, is a key player in the regulation of cell death and survival, making it a promising target for research aimed at understanding mechanisms underlying cancer progression and treatment resistance.
Its involvement in apoptosis and cell signaling pathways highlights its potential as a therapeutic target for the development of novel cancer therapies. The BIRC6 Polyclonal Antibody is instrumental in elucidating the functions of BIRC6 and its role in various physiological and pathological processes, providing insights that may lead to the discovery of new treatment strategies for cancer and other diseases.
Antibody Name:
BIRC6 Antibody (PACO18943)
Antibody SKU:
PACO18943
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:3000-1:10000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human BIRC6
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO18943(BIRC6 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18943(BIRC6 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.
Synonyms:
baculoviral IAP repeat containing 6
UniProt Protein Function:
BIRC6: Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Homodimer. Binds the activated, processed forms of CASP3, CASP6, CASP7 and CASP9. Interacts with RNF41, DIABLO/SMAC, HTRA2, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8. Expressed in brain cancer cells. Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9.
UniProt Protein Details:
Protein type:Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.19; EC 6.3.2.-
Biological Process: mitosis; apoptosis; cell division; positive regulation of cell proliferation; protein ubiquitination; regulation of cytokinesis; protein amino acid phosphorylation; negative regulation of apoptosis; regulation of cell proliferation
NCBI Summary:
This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]
